Proven Protection With a Low Median Dose

Adjust regimen based on patient response

The recommended starting regimen is

• 20–50 IU/kg for patients ≥12 years
• 30–50 IU/kg for patients <12 years

Patients <12 years may require more frequent or higher doses.

In AFSTYLA clinical trials, median doses were

• 2x weekly
  • 35 IU/kg for patients of all ages
• 3x weekly
  • 30 IU/kg for patients ≥12 years
  • 32 IU/kg for patients <12 years