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Read Important Information on Helixate® FS, Antihemophilic Factor (Recombinant)

Read Important Information on Helixate® FS, Antihemophilic Factor (Recombinant)

Once Activated, AFSTYLA
Is Identical to Endogenous Factor VIII

Unique mechanism of action
(MOA) leads to increased
stability and long-lasting
protection

Like naturally occurring Factor VIII, AFSTYLA binds to von Willebrand factor (VWF), which helps protect it from degradation in circulation.

The novel single-chain design of AFSTYLA allows tighter binding to VWF, resulting in a more stable complex that can last longer in circulation.

AFSTYLA is the first and only recombinant Factor VIII with a single-chain design

  • Heavy and light chains of Factor VIII are covalently bonded into a single-chain structure.
  • This allows increased binding affinity to VWF, protecting AFSTYLA from degradation in circulation.
The novel single-chain design allows tighter binding between AFSTYLA and VWF
ONCE ACTIVATED, AFSTYLA IS IDENTICAL TO ENDOGENOUS FACTOR VIII.

Discover more about the PK profile of AFSTYLA

Discover more

PK
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